I wouldn't hold your breath... If it does happen it will most likely be after the game is fully completed for a second play through. A change that fundamental to the core structure of the game would likely require EVERYONE to make a full restart. Most of us have far too many hours of gameplay invested to be willing to do that. I'm sure there will be more futa/trans content introduced as we go along as additional characters are much easier to add than changing the MC and the entire game with that. We have seen the banker, our futa in law, patriarch of our dear wife Sophia attending the brothel to frequent our courtesans during our CCTV observance training during working hours and we now have a futa running our human dairy operations as well... you even get the opportunity to fuck her pussy while the doc is milking her cock for futa cum samples.
At present, Sophia is pregnant with heir number 14!!! I am current and complete on all quests to date and there is no way in hell I want to start over again. Futa protagonist will be a great idea for a post completion update for a second play but not until. I'm sure there are many others not willing to start over at this point for such a change. I know I am one of them.
Adventure ever on, Phat