Basic answer is your guide is very handy here as it keeps track of all the clue types you find over runs and worst case just keep trying till you fill it out. Just as a fair warning to get all the content (not full guide as that is many more runs but just unlocks) you will need at least 3 runs so don't expect to one and done this anyways.
A bit more spelled out there are 4 clue types, whichever you have the highest of will determine which result you get:
Forest - which is a fake and is useless
Hypnosis - Which just leads to some conversations but no unlocks
Bedroom - Which leads to a scene with 2 unique unlocks
Mystery - You must have all 4 and these lead to Haily and the 2 unlocks in that scene that can't both be gotten the same run. Once solved once you get a button added to just know where Haily is for later runs.
Full spelled out and spoiled to hell and back