Lisa is probably a guaranteed ending - the Power Trip ending, which is like the safest ending to cover your bases. You just straight up marry the CEO of your company and you rake in billions of dollars together.
That is so not how that works, bro. Given that we heard nothing so far about stock prices droping, Polygene is probably privately owned by James and Sarah. Now given their expertise, James was probably the CEO and Sarah the Head of research, or they shared the CEO responsibilty. Lisa was either the COO or CFO at the time of their death, because those are the natural successors who would inherit the title of Acting CEO, just as Lisa did.
However all of the C's are employees, whereas MC and Jaye will ( and already should have ) inherit
ownership of the company, meaning they already are both billionaires and never have to worry about money again.
Wether either one of them is actively working in the company does not impact that, if they wanna live their own lives and not be a part of the company, they can appoint Lisa, or anyone else for that matter, as the CEO, pay her a Salary ( which would be nowhere near billions, prob more like low single digit millions ) and then the MC and Jaye would get their equal share in the companies profit.