It is not impossible but remains improbable. A temptation that you already know will lead to nothing is not a real temptation
Sure, but there's no reason to pigeonhole Lisa into being a mere temptation. It's entirely possible to see her as side-girl the MC can have some fun with when he's not on either LI's path; the fact she can also serve as a temptation to MC who *are* on a path is a bonus. Now it's true that any action with Lisa will ultimately be a one-night stand, but so what? That's the lot of a side-girl. No sense acting surprised about it now.
in this game it was a "problem" that Jaye might not be a virgin (and because of that create one of the most pringe moments in the entire story)... it certainly would not have been an advantage if in a previous game she had been interested in someone else.
but then really that's not even the issue: once it is established that they are going to be protagonists in a new story, everything they accumulate in this one would only be an obstacle to the freedom to tell this new story, and they already have very few constraints on them.
True, people complained about Jaye's lack of virginity, but so far the devs have stuck to their guns about it. IMHO, that's they should; I find the obsession with LIs being virgins borderline creepy. Other people are free to disagree, of course, but that may ultimately mean the game isn't for them. You can't please everyone all the time, and trying to do so is a slippery slope to mediocrity.
Assuming the devs hold the same philosophy in their next game, I don't think Lisa's time as a side-girl in this game will necessarily limit their freedom. Why would she need to get into details on this particular one-night stand? Even in
Chasing Sunsets, Lisa already implies she's learned to "cultivate opportunities" where she can. The implications of that seem clear to me yet we never go into details, and it doesn't seem to damaged her popularity. The same blueprint should work in the next game... as long as the devs are comfortable with Lisa having a nebulous history once she's promoted to LI. Hopefully they will be, but we'll see how it goes.
Personally, I think Tara is a much bigger issue because the events of this game are FAR more central to her story. But even that can be worked around as long as the devs are willing to cut bait by the end of
CS and establish unambiguously that Tara is over her earlier infatuation with the MC. Of course, there's no guarantee they'll catch lightning in a bottle with Tara again, but that's the risk they need to take to pull this off.