Start with just the DAZ base Genesis 8.1 (or 8) character and then adjust sliders/ character presets.
I started using Zeddicuss's shapes and then character heads and then adjusting sliders from different morph packs (mainly EJ's body and shape morphs as well as face and head packs). Hardest thing is getting read of unrealistic curves (over done hips and ass mainly). I use Stereo Love to adjust the hips and ass after upping a preset.
Heads, use anyone you want as the skin is the most important part. I've been using Mousso, Raiya, Emrys, Colm Jackson for the head shapes. Find one you like and use it, or find aspects of multiple you like and adjust the sliders. I find it easiest to find one you really like and set it to 80-90% and then lower values of the others you might just want some of the mouth or eye or nose shape of. If you go to heavy throughout the character may start to look like they had WAY too much plastic surgery and a super scrunchy face. You can also just use one at 100% and then use EJ's face and head morphs to adjust specific areas.
Then its picking a good quality character skin and playing around with it. I really like Mousso's characters, Emrys is good as well and has good customization. Babina 8 is one of the best you can get in terms of quality, but its tough to easily get makeup changes.
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