Very much so. Most of the character paths are mutually exclusive, so choices matter on the granular level. For the over-all plot, there's a handful of bad ends to be avoided (not that difficult) and some choices that
seem to give better results than others in the investigation, but it's yet to be seen exactly how that shakes out.
Gallery update, website overhaul, achievements and other fluff are yet to come. If you're just interested in Ellie's path, you should be good until 0.14 rolls around.
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