Hit boxes really need some work... some weapons refuse to give you the little red targeting reticle/dot, then it will appear for a brief second and disappear again. Frantic spam clicking is the only way to overcome this it seems, hoping you'll magically click in the correct spot when it appears (good luck). Some of the bladed weapons seem to be the worst offenders, I think it was Daybreak? or maybe a rare scimitar, I can't remember. Didn't have as many issues with this just using the basic mace. Also, you seem to encounter it more as you progress, maybe since the enemies start wearing more armor? Do certain attacks require you to target certain parts of the body or something? Enemies with cleric robes seem particularly fucky, or maybe I just had bad luck here. I dunno, very frustrating though...
When this happens you can get soft-locked in combat if the target cursor never appears, so save regularly and frequently to avoid some of this pain.
Dev should at least give players the option to cancel an attack. This way, if you get soft-locked because the reticle doesn't come up, you can at least change to a different action.
Balance issues have already been mentioned quite a bit by other players here so I won't go into much detail on that except to echo their sentiments-- some weapons are just downright terrible to use, but I'll add that attack card descriptions in combat should be more clear in how much damage they will actually do. It's pretty obnoxious when you have an attack that says it's gonna do 154 damage (Hew) and in practice it does only 5.
It was during the third combat in a row where I got soft-locked while trying to test out different weapons that made me realize I wasn't having fun anymore and decided to put this game down until it's closer to completion. I think I'd seen everything there was to see, however I couldn't seem to start any of the overworld expeditions so I'm not really sure what that was about either. Maybe I missed something, the tutorial said it was available but I couldn't figure out how to access it. Rather than hide access in an obscure UI or room submenu, you might want to put a button for it in the bottom right corner with the other 'core features' -- assuming overworld expeditions are meant to be a major feature of the game.
Good luck dev, keep with the steady updates and I think you'll have a success on your hands if you can finish it.
tl;dr: biggest recommendation: address bugs and balance before it gets too out of hand or you may chase your early playtesters away and tarnish the quality game you have brewing here. other than that I'm looking forward to future content!