Hello, tried the game, here some thoughts:
I like Mary's design (big tits that sag from their weight) and graphics (very nostalgic), missions that remind of old games.
If You going to keep adding extreme stuff, I would recommend to make SubscribeStar account.
I think it's better to focus on one protagonist, Mary, her story and corruption, to avoid game becoming a scene collection with different characters.
What can be added:
Sex toys, game needs things to waste money on, since it has no guns, it can be wide "arsenal" of toys to use at home, starting form ordinary and leading to huge absurd dildos buttplugs and sex machines.
With so many creampies, pregnancy is obvious possibility, don't know if it considered, maybe give her fast gestation from virus (only she has it as patient zero), with pregnancy duration of week or two, contraceptives to buy.
Lactation (from pregnancy or drugs), dairy cow work in Japanese cafe, with thick nipple rings piercing given to her.
Talking about extreme, what about bestiality? Is it too much? Mary starring in "dog show", or during some mission she has a choice to take a dog, finding out that now she's a "pet" in her own house (also option to use it instead of boring masturbation).
Hole stats menu, can be purely cosmetic or used for quests, for example Mary won't be able to take some missions with too tight pussy or won't interest clients if she has blown out cunt (also way to spend money, on rejuvenating creams and gynecologist).
More options in gloryhole with offering pussy and ass, opening gloryhole business and hiring workers.
Most likely already planned porn filming (with appearance of guest star Candy Suxxx), and starting own porn production when Mary finds out she's underpaid.
Missions of seducing people to get discrediting photos on corrupt politicians, priests, and for divorce.