Just to let everyone know, I tested a bit Nemeses today and it's definitely not list material as both of the 2 giantesses you fight are futas. (well, the game only mentions they have a "penis-shaped predatory organ", but that's just another more sci-fi way of putting it) Fetishwise it has spitting, trampling to death and seemingly a lot of farting and bad-breath content, so if anyone here is interested in those for their own sake you can take a look yourself, but I haven't played it for more than 15 minutes because "giantesses" are a bit of a secondary kink for me, and if combined with futa it's a total turn-off.
I can like giantess content if it focuses on the protagonist's powerlessness in front of them, on them enslaving or using and abusing the protagonist for their own pleasure in ways that endanger MC's life or... skeletal integrity, on them being very dominant in general (not just sexually) with the added power-inbalance that the sub MC is a mere spec of dust before them or, in a more loving-femdom context, if they are actually revered goddesses in a fantasy universe (that either are so naturally or can will themselves to a giant size on a whim) and MC is a devoted worshipper, but I won't like any content that has giantesses just because it has them.
I also have a realism pet peeve with any content with humanoid giants, female or otherwise, set in sci-fi or even as technologically-advanced as the 1940s universes, as it always grossly overstates the power of a colossal biological organism. Flesh, no matter how think and muscles no matter how strong, will be obliterated by mobile surface-to-air-missiles like a unit of ww2 Katyusha rocket launchers, and no bones will survive even a conventional bombing raid with B-29 bombers, let alone a nuclear blast, so I find the idea of a few of these beings defeating human modern armies ridiculous. Hell, there's technically even the physics problem that any being with a human-like shape would collapse under their own weight at that size/would not be a viable organism, so the only way I take Giantess content seriously is if it's in some kind of fantasy universe where magic exists or the laws of physics are different from our own. (or if it's predicated on MC shrinking down to a tiny size, not on the giantesses being the size of the Eiffel Tower) I loved some of the content and lore in "Giant Guardians", but if Giantess content attempts to be pure sci-fi or set in our world I just can't bring myself to take it seriously...