There are a handfulos pretty serious bugs that I encountered. Some of them throw you around between the routes, and some completely softlock the game.
hey so i just tried it and did a start -> finish playthrough and the only soft-lock i found was the goblins. after she gives the chief a handjob the game tells you to go into the tent but you cant, and despawns all the other ways to get into the city, so you're stuck. but besides that - if you do the routes i did:
1. Rokas's route
ONLY to enter the city
2. renting a flat route
3. romance Lazlo route
4. prostitute outfit route (to get into the red light district)
5. get amy tipsy + bail Frank out route
i got a (suprisingly) soft-lock free playthrough. there were minor visual bugs but that's about it. no guarantees if you go with other routes e.g. slave route or military route or whatever else there is, ive only tried those other routes in previous versions of the game
although, the gallery is totally busted as people have pointed out before. if you use the save file provided in the early access version it tells you the save file is out of date and you cant get inside. or alternatively if you finish the current version to the end (like me) it will infinitely roll credits and not let you inside. i just edited the gallery with mTools and now it works/has all the scenes