Nana is just straight up not avoidable. Nana, Cat, Liz, Amy, Jamila, Shizuka and Asami are all unavoidable to so don't need to worry about those 7 gatekeeping other LIs. The ginger family, Riona, Ella and Ellie are all dependent on being on Fiona's path but she's a fucking smoke show so no worry there. Paveena requires you to be on the doctor, Priya's path. I believe Jada, the black milf, requires you to be on her daughter Aaliyah's path. If I remember right that's all the missables.
Either way, don't be a pussy and just go for them all. No point in cutting out huge swathes of content just because you're not immediately attracted to a few of these babes, either they'll grow on you or there's something just plain wrong with you.