I was just looking at the tags for The Artifact trilogy...
There is time travel involved, which confuses things, but besides Mom and Son and Brother and Sisters, the MC (Son) has sex with his Aunt, Grandma, and Cousin(s) as well as Mom and his Older and Younger Sister. As to which parts, checking...
That's about it. There's also pregnancy involved, which complicates things... for a RPGM game, this trilogy actually isn't too bad, as there are minigames (those annoy me but points for effort) and the walking isn't too overly bad IMHO as minimaps pop up showing you where you need to go fairly often (always maybe?). Plus, you can usually replay the minigames until you 'win'... it's been a whle since I played, though so some of this is from memory. Just started playing Part One again...
My Enthralled crossover comic has a fair amount of incest going on (F/D, B/S, Grandpa/Granddaughter, M/S isn't actually shown, see the 'homaged' game Dreams of Desire for that action,and some multiple partner incest action...) but it's not a game, although it does feature characters from at least five games, four of which are listed in the OP of this thread. Also, I 'incorporated' two characters from one game into a family featured in another game (Katie's Corruption, Milf's Villa). Might be worth a looksee for those that have incest fetishes...
One of my 'homaged' games is Teacher's Pets. AFAIK Father never actually had sex with the daughter in that game (abandoned too soon), but I gave another character, Meghan, a dad for my crossover comic. Since no F/D sex happened afaik, no point adding TP to the list, unless handjobs count... TP is mostly just a big tease at this point. Just wanted to clarify why I mentioned five games r.e. Enthralled...