Ok, so when I first ran 29.1 it ran fine, I walked around a bit, looked pretty much the same as previous versions.
I then decided to delete my save file to see if there was anything new in the character creation screen. After deleting the save files. The game starts and then lockups on the loading screen. Tried a few times and it locked up everytime. A dialog pops up after a while (120 sec?) saying that the game was unresponsive.
Weird.... 29 worked ok when I unpacked it... maybe it doesn't like starting with a clean slate?
I then went back to a prior version (27?), created a character, walked around a bit and quit the game. Now when I start 29 it gets past the loading screen and makes it to the main menu (with the continue option) and the character crouching near the bridge.
From here, task manager just reports the process as having 4gb and stays 'unresponsive'. I leave it for a few minutes and the dialog doesn't show up here (which makes sense because I can understand players sitting on the start menu for long periods of time)