I'm fresh off an Alexis secret path run so I might be a little biased but here goes:
1 Nikki- She's pretty much perfection. Almost too perfect. Sorry, Cara.
2 Alexis- I know she's one of the major sources of drama in the game but I love her look and her main route is my 2nd favorite, only beaten by the secret path. I really enjoy the chemistry she has with MC.
3 Valeria- Looks alone put her over Layla. I wish she was written a little less mysterious, because it makes me want to overthink every facial expression she has.
4 Layla- I really enjoy her route and helping her get over her past experiences. Definitely nice for the runs where you don't want as much drama.
5 Elena- Only below Layla because you're pretty much required to run Layla's route and then break her heart for Elena.
6 Gabi- I wish she was a main LI but I get it. On runs where I play the MC kind of shitty, I always gun for Gabi.
7 Iris- She's a little too aggressive for me. I liked the building of the relationship in the flashback but I'm not really into current Iris, she just kind of exists, and I humor her.
8 Erynn- Remove the whole blackmail plot and Erynn jumps to 3 for me. She's just too damsel in distress otherwise.
9 Cara- Nikki absolutely kills Cara for me. I'm sure she's nice enough, and I've done her main route but there's just no chance here.
10 Melissa- Melissa is hot but until there's an actual route, I just don't see how Nyx writes Erynn being okay with MC doing anything with her mom. Even on routes where you are friends only with Erynn, I just can't see it. Thus Melissa just feels like eye candy and teasing at the moment.
11 Tori- Two things going for Tori. She plays her role well and the sex scenes are hot. That's all I really care about her.