In relation to the Main LIs, I would caution that, yes, but that's only confirmed to this point. However, once all the out-of-town ladies arrive in to town, and the in-town girls find out about each other, fireworks are expected... and not in a harem-friendly way.If what you want is unlocking the gallery, single character runs is the slowest(and boringest) possible way to do it.
You can get all the Alexis, Nikki, Val, Gabi(plus miscellaneous chicks) in a single run.
You can also get all the Erynn, Layla, Rachel, Elena, Cara and Tori in a single save, that's almost everything in 2 saves.
Some scenes, like Julia, peaking at the girls in the shower... it's best to do it then reload immediately cause they are just dead ends.
You'll also need ASP for couple of scenes, with Alexis herself and Iris... it automatically gives you the Layla stuff, you can also use your ASP save to combine with a Riverside sister, Gabi or Elena.
The key to be an "efficient and organized manwhore" are the Monroe sisters, they determine were the game splits.
If you go with Layla, you can have Erynn but not Val, Elena only has scenes with Layla.
If you go for Alexis, you can have Val but Erynn is partially blocked... and since you won't have Elena anyways might as well go for Gabi(Gabi and Elena also block each other).
Or you can just cheat...
I would hope there'll be some memorable fireworks scenes for a gallery, but I'd be extremely disappointed if at least 1/3 of the single paths closed off, as it just woouldn't fit the characters.
Although... if you take the "manwhore" route, it'd be cool if it had it's own "Sadly Ever After" achievement as all the ladies leave you. And the end scene, is the MC sitting back in the distance watching all the ladies party at the beach with other guys.
As to the Side Girls, I would be interested to see if any of them become bitter the MC treats them as a side girl while dating someone else and things go downhill.
