I took all the edict available with 1st level not subjugated.
I try to stay alive (boost stamina, mind, energy, willpower), spam the charm increase in willpower phase, use flaunt, handjob, boobjob to make them cum, but the problem is that Karryn's pleasure increase too fast.
so let me point out some mistakes. first off, you need to get healing thoughts ASAP, then make mind upgrades your first priority. "orgasm resist" and "increase X pleasure" edicts are must-haves later on. you can put 1 point into endurance to take less dmg. another option is to improve your sleeping conditions. the improved bedroom makes Karryn start the day with more energy. critical point is, u have a lvl cap on each floor. after each fight, u get xp based on how u handled the enemies. so early mind upgrades are essential to get more xp for that stat.
try to get some accessories to increase your mind/energy (ez with infinite money).
early game fights: don't
spam charm increase. keep your willpower to use healing thoughts. one flaunt on each wave of enemies is enough. focus on ONE sex attack. they do lvl up themselves and they deal more dmg as u lvl them up. don't fight in the bar, take your time and do not try to clear the whole floor without resting. my personal favorite strat for day 1 is clearing 2-3 rooms and then losing the bar fight ON PURPOSE to get my sex skills faster. if u want to keep her a virgin, don't do this too often.
I don't remember how, but u can get lady and secretary stances. they both reduce the amount of pleasure Karryn builds up and are quite useful early on to drag out fights and make enemies cum before Karryn does.