Yes. I had this when I first installed r2.
I don't know what causes it.
It required a full reinstall with a fresh download to work again. After I did that, I have yet to ever have issues. I think maybe there was a registry conflict or something.
So I did that inbetween making my post and now, and while it did allow me to start a new game, I cannot save or load, and when i launch the actual game, i am locked in place, I can run, but not move from that spot or turn, and various hair pieces/accessories from the girls are stretched from their position to my characters. I tried using the teleportation control to move around the island but it still prevented my movement from the origin points of each place respectively. Again that was after a full reinstall. The full reinstall also fixed an issue I was having as far as certain outfits looking excessively shiny, but with all these new issues that render the main game literally unplayable I'm finding it increasingly difficult to want to play.
I appreciate your response and don't expect you to know what my game's issue is or troubleshoot it, but I guess I'm just putting this here in case anyone else scrolls through and wonders if it only happened for them. Thanks again for your response.