Not sure if joking, but let's go down that rabbit hole.
The Persona series has been cited by Selebus as an influence on the game. For anyone who was unaware, the modern Persona games feature high school students in their second year going through some form of rite of passage into adulthood. They use the Tarot Arcana to symbolize the stages of passage from the innocence of youth (The Fool) to the maturity of adulthood, and each of the people the The Fool meets on his journey symbolizes a step on that passage. There are usually 20 Arcana in the initial version of the game, though the enhanced release may add some additional Arcana. But 20 Arcana for 20 Main Girls may be relevant.
Persona 3 is a game about accepting your own mortality. Persona 4 is a story about overcoming your insecurities. Persona 5 is a game about moving past your personal trauma -- which seems particularly appropriate for LiL.
The game takes place in both the "normal" and "shadow" world, though the nature of the shadow world varies by game. In 3, the shadow world is a localized distortion centered around a single location that only exists in a period of time that most cannot percieve (the 25th hour), in 4, it is a "TV Realm" literally entered by passing through a TV screen (note: thsi game came out before TVs got as large as they are today, and finding a TV large enough to fit a person through was still a bit of a challenge), and in 5 the shadow world is the world of cognition-- or Perception, but as it exists in a collective sense.
When a character is in the shadow world, they might awaken a Persona -- a spiritual being (drawn from religion or literature, usually) who grants them incredible power. at this moment, their outfit changes to reflect their awakened state. Ayane is wearing the costume of Ann Takamaki, a model who is being sexually harassed by a teacher at her school. Her refusal of his advances causes the teacher to rape her best friend, who then tries to kill herself by jumping off the roof of the school. Ann's arc is driven by her sense of guilt towards what happens to her friend, her dealing with rumors (spread by the teacher) that she was sleeping with said teacher, and a desire to not be seen as just a model anymore.
A whole lot of that is really, REALLY on the nose.
Ann is the Lover Arcana, which seems appropriate for Ayane as well.
Other characters in the game include:
Futaba Sakura, a redheaded Otaku recluse who blames herself for her mother's death (Molly?). She is the Hermit Arcana, which is less appropriate for Molly (Yumi would be a better candidate)
Makoto Niijima, a studious Student Council President who blames herself for not seeing what was happening at her school sooner. Her Arcana is Priestess, which doesn't feel like a good fit for our Makoto (Noriko is a better fit), but the name and role overlapping likely isn't coincidence.
Haru Nokumura, an heiress who is slated to be married to the son of a company executive who is also an abusive prick, who feels abandoned by her father (Touka). Her Arcana is Empress, which also fits Touka (one of the first things listed on the Megami Tensei wiki for Empress is that it's associated with mothers, and we know how Akira feels about Touka)
Kinda just punching the nose over and over again, honestly.
I've known that Sel has cited Persona as an influence for some time, but I hadn't actually thought that much about LiL in terms of Persona or the Arcana.