I mean Ayane can't blame Sana for not being the girl in Ayane's mind.
On the other hand, when your friend's characteristic features are total opposite to what she shows, ıt is totally understandable you may be disappointed.
What i wonder is what is gonna happen between them from now on. Next update probably will have something about Sara/Sana relationship, but what about other characters? Nodokathon 2 was so huge that we should see it's direct consequences in terms of character intereactions between girls. But i have a feeling we wont see that.
Yeah, Sana isn't Ayane's emotional support animal. Ayane just struggles with things not being how she wants them to be.
As for Sana and Sara; considering that what happened was optional, I doubt it is going to amount to much, besides maybe a depressing threesome, while the Sakakibaras medicate with alcohol, and a few lines of dialogue here and there. I don't see what Sara can really do besides drink and get over it, then bond with her daughter, tbh. But, we'll see.
The same goes with most of Nodokathon, since it was optional.
I am somewhat hoping that Ayane and Sara talk about Sana next update, though. Maybe even Ami gets involved since she likes Sara.