I'd be more worried if she had like 3 events and it was 15 main events. There has to be enough Ayane there for it to be an Ayane event so she can't just be reset, previous experience would teach us that she'd respawn at a natural point for her or something to be woven back into the default story aka not enough Ayane for 12 events. 0.50 literally just quoted Akira as saying If another girl resets in his hands during sex he's just gonna castrate himself so he's gonna be avoiding that during the reset (at least on the rooftop where this stuff apparently happens). There's also been no threat of punishing Akira again if he doesn't do something this chapter, so someone getting reset out of nowhere seems very unlikely.
It would make more sense for Akira and Ayane to be together during the reset like part 2 of last reset in another timeline, or maybe the backrooms at another office branch. We're due more exposition on how the world works. There is a timeline where Ayane gets to witness and maybe contribute to the next reset puzzle. Also one where Himawari is just there too so its a full Mother Father Daughter adventure. There's also a chance for the sensei quest stick and nothing to bear fruit of some kind. Part of me wishes we'd do something with the shampoo which could technically still exist in your inventory but Sel would have to do a patch job to stop it being red path now, which isn't impossible it's just never happened before.
If we're talking about something to be worried about, I noticed there were a lot of references to rape during 0.51. If we're talking about things that have had god instructions for Akira to follow, including how to get Maya back, that'd be it. Others have noted how much Sel is flirting with the idea of a rape scene,
I've even posted a prediction about who it would be.
Just taking into account that, okay, she can have several events so we need her for them, but that doesn't mean she'll be fine at the end of them, I'm just saying that it would be better to already be prepared in case something bad happens to her, it may not be a reset, but imagine her character really disappearing? Like, Maya Prime was reset, but we still have this other Maya, but now imagine if Ayane herself disappeared for good? We have to remember that in chapter 3, the first time Ayane arrived on the terrace and the reset happened, she "disappeared" she wasn't with Akira and Maya, which could end up making this a foreshadowing of what will happen to her in this next reset.
About the rape, I don't think it will be that, honestly, at most it can happen with Akira being controlled to do it, but I don't think he would do it himself, especially since currently there are very, very few girls who would refuse to have sex with Akira, from the examples you mentioned, Otoha himself was already flirting more with Akira, and Osako can defend herself from him easily, of all the main girls currently I think the only one who could resist this would be Tsuneyo, and that's just speculation, since she's very interested in him now too. Of the secondary girls, who are they? The wizards? 0 chance. Selly will do it to hurt them, and if he does, it will be rape, it will be more focused on the rape than on the character, being wizards. Wakana? She's also getting more interested in him. Rika, maybe? Unlikely too. Like, to me, this theory that Akira will rape someone makes no sense when 99% of the cast wants to sleep with him. This theory could make sense at the beginning of chapter 4 and in chapter 3, but currently it doesn't make sense when they all want to sleep with him. And if they talk about Karin, she already avoided that, and Selly obviously won't repeat a similar situation with the same character, that's why I genuinely think that this theory doesn't make sense, it may have been something done only in chapter 3 for people to get anxious and worried about whether Akira would do it or not, but currently it doesn't make sense anymore when 99% of the cast wants to sleep with him.