In my opinion, with hair open, she looks waaay too much like Tracy from Dreams of Desire. However, the messy ponytail that she has for example in the shower looks way better on her than that "original" she has. But then again, that messy ponytail is like one of the most used hairstyles in these games, so it wouldn't make the character stand out as much as it now does.
Still the biggest issue with Isa that I've had since the beginning is how (at least to me) she looks more like an aunt than older sister. Like yeah, she's clearly younger than Joyce, but still looks like she's 10-15 years older than Connor and Ruby, meaning she'd be in her early/mid 30's instead of the supposed mid 20's.