Looking forward to the game answering some questions. If the MC refused the sex ritual with Sofia, who does she do it with instead? Will Anna return to enroll at the college? After the femdom scene with Dragomira, the screen flashes red and she looks dizzy and woozy. What caused this? Finally, if you allow Dragomira to suck your... blood, can MC now become part vampire himself?
My speculations on that:
Sofia needs serious encouragement by MC to have sex, it is likely she would get anxious with other participants as well. Meaning she likely won't unlock her full witch potential if MC did not do it.
Maybe she overcomes that restraint/guilt/fear with John Doe, but it is unlikely since MC is the first person in a year that was willing to help her. She was all but ignored by everyone else.
With Silverleaf on lockdown she can't go to a bar in the next town to find a one-night-weirdo even if she wanted to.
Whether Anna returns to the college apparently depends on how the MC treated her at the farewell. If he asked her to be in the harem apparently she is in the story going further, and that means she likely enrolls. If MC did not ask her to join the harem she is gone for good.
The screen flashing red likely meant that Dragomira got thirsty and the MC sensed that as a sort of warning.
Not a spidey sense but a wolfey sense so to speak.
Usually neither werewolves nor vampires can get sick. Vampires can't get sick because they are dead and werewolves usually have an immune system "on overdrive". Meaning his werewolf blood would combat the vampire infection similarly to MC being unable to "pass on the gift" to Rachel or Dragomira.
Plus usually it is not enough to have the vampire drink the victims blood, the transformation is triggered with the victim drinking the vampires blood after.
So no. The MC won't become a hybrid werepire through this.