I am not sure if the patched version fixed this bug or not, or if it is just exclusive to my save (I am currently trying to get to said point with a fresh save to see if it is exclusive but if someone else experienced this bug please let me know) but if you are playing the OP version without the patch (Not sure if it is 6.0 or 6.5) here is a bug I saw in my play through. With the Markus mission where you go to his cousin's house to get the weed, if the timer reaches 0 it doesn't reset and the game goes back to what it would be like normally (minus having Markus follow you and the cops in certain spots going nuts)
If you do run into this bug DO NOT SAVE YOUR GAME! Either reset it normally, or run into the cops and get a game over so the game can reset. If you make the mistake I did and save you will effectively corrupt your save and will either have to use an older save or if you don't have that start from scratch.