Works for me. If you're loading up old saved games, that could be a problem if you used a mod with them and not now, or you use one now and not then? Does the game take you to the main menu?
You may need to start from scratch (I did that myself today as it has been a while anyhow). I went to "%appdata%\RenPy\OhDaddy-1626454802" and deleted all saves and persistant. I also deleted all saves that were in the "game\saves" folder for the game itself. If you have to, maybe delete the game install, delete all saved games etc... in the "%appdata%\RenPy\OhDaddy-1626454802" folder then re-install the game fresh and it should run and you could start a new game.
note, you can enter %appdata%\RenPy\OhDaddy-1626454802 exactly like that and it will take you to that folder on your system (if it is windows anyhow). It's short for "C:\Users\<yourname>\AppData\Roaming\" on Windows.