Hahahahahaha I don't blame you, I've played many times and every time something appears that I didn't know, recently I discovered that we can change to Jessica in astral travel, which is very crazy and convenient.
This is a very recent change by Eva. Something I think gets overlooked a lot by the community here, when they complain of short updates or whatever; is that Eva spends a pretty good chunk of time going back through the earlier stages of the game and adding / changing dialogue so that it lines up better with current events. Or, as you found out, hides the ability to change Jessica in the drug sequence, which is actually incredibly clever.
So I was digging through the checks for the chapter 12 MMA fight when I stumbled upon this.
Thoughts?
I'm betting that many of those are potential variables, similar to Lena and Holly's numerous tattoos, that are added as a "just in case." They might not all get used, but they're there on the off chance that Eva does decide to implement everyone getting into fights. Jeremy and Mike make sense as they're both in the MMA tournament, Wade makes sense on the off chance that he finds out about Cindy and Ian. Seymour, Mark, and Axel are the more interesting ones.
Somewhat on topic. I would really appreciate a route with Lena or even a sluttier Holly, gets kind of turned on by a violent Ian. Like Ian can already have a tendency towards violence, by immediately jumping Robert twice, Milo in the streets, and physically putting Wade down instead of talking him down; so it would be great if Lena, or Holly, could respond positively towards that. That they find it "hot" that their man can beat your man, type of situation.