Not gonna lie, Alison going full manipulative bitch and antagonist would be based. I mean think about it, she gets cheated on wholesome route = drama = based. Bimbo Alison is more about having fun and she does not care too much about the casualties but not sure if there is more to her.
Slut Holly having some sort of development would be pretty wild like more manipulative or simply developing some sort of interesting personality trait beyond Ivy's slut starter pack(although her fucking some guy that leads to complications would be fine too but the question is who would even cause such a thing at this point) Wholesome Holly essentially requires conflict for her route to not be too boring(her having a hot sister leading to complications or simply either Holly having the possibility of her fucking Ian's dad would be wild).