Money and power are means, not ends.
A character might want to acquire money so they can lord it over a hated foe, or explore unknown regions no one has ever been to, or to have the greatest collection of <whatever>.
A character might want to acquire power so nobody can ever hurt them again, or because they think they understand things better than anyone else, and only they can guide a group/nation/humanity through clashing rocks.
All too often antagonists in fiction are left with cloudy motivation and generally only exist to provide the protagonist someone to fight and ultimately defeat. I find this shallow and ultimately unfulfilling, I don't just want to know what the antagonist wants to do, to me I want to know WHY they are doing it. I appreciate that not everyone cares about this, c'est la vie.