Oh, so there is a known issue with saves at that specific spot; I put it in the known issues but I guess that wasn't posted here. There's an engine bug that the position of a panned screen doesn't save, so it kind of makes things seem all messed up, but only really at that particular point. I was hoping for the engine issue to get patched out but I might just have to develop a workaround myself rather than waiting for it.I want to say it happened on a couple of saves, but I already finished playing and deleted so I can't go back and check. There was one in particular where I know it gave me trouble though. I saved at street level before entering the subway when you go to the casino, and when I tried to load it was hanging to the point where I closed out, restarted, and tried loading again at least a couple of times. I don't know if perhaps there was something wrong with that particular save, or what.
Related to that save, one time I got it to load, entered the subway area, but for some reason even though the image was the one in front of the subway restrooms all of the clickable areas (pretty sure that isn't the technical term) were from the living room. I don't know if the way I described it makes sense, but moving the cursor around the screen in that map/restroom area, I'd get the text pop-up for living room/library/kitchen/etc.
The behaviour you're describing does admittedly sound a little weird, but I suspect it's probably because of that bug.