When I tried to exclude the specific file game.exe in Windows Defender, I got a message saying this file couldn't be excluded because it contains a virus lol.
To get this to run on my PC, I downloaded the zip file, put the zip file in a NEW FOLDER and named it [whatever], then excluded that entire folder. Don't unzip the file until after you've excluded the folder you've put it into. Worked just fine after that.
Go to Start > Settings > Updates & Security > Windows Security > Virus & threat protection > Virus & threat protection settings > Add or remove exclusions > Add your recently created new folder where you've placed the ZIP file.