So to get the Artifact(s)...
1 is from the Purple, big boob girl ( the one who works at the Pole-Dance studio) - do both her "fetch"quests, find her family heirloom (hint: It's in the Left Map drops from boss) also beat her in the arena.
1 is from Blue Knight-girl with Blonde hair, just "witness" all her naughty sides incl. adult video and then fight her in the arena.
1 is from Right map boss
1 is from Wilderness Ogre/Bandit boss? (this I am unsure of, this should be the first you get)
For Keys:
Bronze - Increase lewdity + talk to Innkeeper
Silver - Increase lewdity + "buy" information aKa perform "special" actions to the dude that is East of both shopkeeper, the one who tells you about some game mechanics.
Gold - Beat all location bosses and talk to Keiser.
Buttons that can be of "Interest"
Z , X , C
H - Undress?
O - Masturbate ( & end rape)
SPACEBAR - Inventory/Menu
Edit: Yeah the "Save" system of this game is busted.
I beat the game but did it in 1 go and was constantly saving along the way, but it "seems" that the game only recognized the first one 2nd "Save" instance, everything beyond that was lost and the file was never "overwritten" I am guessing many people are having "similar" issues.