Almost missed a bunch of scenes with Cara, would be very unfortunate, easily the best character so far.
It is a good idea to not allow the player to quick skip the eye QTE, noticed this happens at the second half of the game when you visit ex-wife, but first half you can easily skip then, which you would if you have already played the game once before. Those skippable QTEs are the most important so far, so even if it breaks the saves it would be wise to just do it once and for all, it would not be too much of a chore to redo everything yet.