Zetsuko
You are right that all superhumans are universally more resilient and harder to kill. If they have enough time (and in some cases a little medical help) they are able to survive almost anything that doesn't kill them immediately. But if you don't have a specific ability to keep your body out of harm (protective shield, extremely durable body like Oskar or strong regeneration) you'll still die if bullet hit you in the head or if someone pierces your heart.
Jake's power requires that you hear him or that he touch you. So everyone who can't hear him is immune. Also, his orders must not be too against the will of the person, otherwise he will defend himself. Even an ordinary person was too much for him (Mia) when he wanted to go straight against her mind. Overpower the mind of a superhuman would be even harder. Using his power in combat would be very difficult, if not almost impossible.
Cross power is definitely not THAT strong because it has a lot of limits
a) You need to see your target well.
Anything that is too fast, too small or too far away will not be affected by your power.
b) Limited reach.
You can only fight at medium range.
And you will also have a problem fighting in the dark.
c) Very limited defense.
Although she proved to have some limited defensive capabilities, they were limited to the goals she saw.
Remember that only one surprise attack was enough to defeat her. Her body was very weak.
BTW
By the way, oneshot kill power is useless when your body is so weak that almost anything can oneshot kill you. In this case, even an experienced sniper is better. A good soldier with a high caliber sniper rifle and a silencer should be able to kill most superhumans.
I mean, what if I took the position of that same sniper, and then used a telescope to look at you real angrily and real hard and then snapped my fingers? Not to mention, the cross grows in size the more she stares at you, but the minimum bare size is enough to kill any normal person, or even a superhuman that would be killed by a headshot. Actually, anything that would be killed by a headshot, could INSTANTLY be killed by erasing a bullet sized X shaped figure from the head...And the initial size of the X is bigger than a bullet. It's also less conspicuous. You can trace bullets back to the place they come from, but with this power you can be the perfect X marks the spot hitman. You just need to give ONE look at your target(s), and then you can even wait a full day, snap your fingers, and all those targets will die.
And before you say you can't mark more than one person, she does in the game.
On another point; Very limited defense? Enough to stop your attacks and break your arms when you hit the flying crosses, so that's a good enough defense for me, far better than the Gravity defense, since this one is also harmful and harder(Even if it's not passive).
In Reality, if Danica had gone against ANYONE else other than our character, in the FIRST ever scene in which they met, she would've instantly won...Cause her power is a perfect assassination skill.
All powers except our character's have problems fighting in the dark, unless they're huge AoE powers in which case they would be dangerous for you even. Also, crosses probably illuminate the area a bit, they do look glowy at least.
All powers would have problems fighting anything faster than them...But actually, not the cross power. Remember, Danica would just need one look at you, after that you're just a finger-snap away from death. It can be while talking, or it can be while you're not fighting, but all she has to do it see you for at least one second, considering every X marks the spot would saw an X clean through you in the game. Not just a fleshwound in X shape, it was a literal X shaped hole through your body, making that effectively an autoaimed, instant bullet would every snap, and if she is able to stare at you longer, that's like a Barret-Sniper level of damage she can deal.
I do have to agree with you on Jake probably losing a fight in the end, but I doubt he would lose against a normal human almost, like, ever. In the game, you can see his first instinct when he is in danger is saying Command: Pain. Meaning any human would probably fall flat to the ground(According to himself), and that even works on superhumans, since the Ultraevolved red haired Blade-woman felt pain(But she was angry and resilient to it, since she's MUCH more evolved, otherwise it might have incapacitated or crippled her)
Edit: This is also the typical staple you face when talking about superpowers. The way you're "countering the powers" is by using gained knowledge...But if you just met Jake for a first time fight, or Danica...You'd probably never see it coming.