So I decided to replay the game following 3 different paths, Power, Skill and Corruption.
Of course as most of you know by now, the most important choice is the arena fight with Michael.
Power vs Corruption:
Power and Corruption playthroughs go hand in hand. They both get unlocked by choosing power against Michael. The only difference between them is if you decide to consume the optional characters or not.
Both playthroughs have the option to consume Kenny. If you consume Danica you can have enough corruption to force the Myniak to submit. There doesn't seem to be any check for eating Danica or Jake.
The difference between a Power and Corruption walkthrough is 4 corruption points (32 vs 36). You can also gain one more corruption point if you kill Demi.
Frankly, high corruption score at the moment doesn't do anything. The only indication that something is happening is if you consume Jake because the MC can "hear" him during certain scenes, but this scene happens no matter how much corruption you have.
The Power and/or Corruption route requires the Horn to gain Valravn's respect. The highest power I could get was 73.
Skill:
The skill playthrough stays 1 skill ahead, 3 Power behind and 5 corruption behind a full power & corruption playthrough. The player trades the capability to eat Kenny and trigger Ella's deadend sex scene for the capability to get Valravn's respect without the Horn.
Currently there is no other benefit to the high Skill playthrough, especially for those who want to save Laurie. Perhaps the eye may become useful in a future update. The 28 skill check against Monster Deryl just requires the player to have finished all side stories before going to the mall as most of them come from the cheerleading practice.
So this is my opinion for the various playthroughs:
High Skill & Care about Laurie -> Not worth it.
High Skill & Not Care about Laurie -> Worth it.
High Power & Low Corruption -> Worth it.
High Corruption without eating Danica/Jake -> Works exactly the same as High Power & Low Corruption
High Corruption with eating Danica/Jake -> The only way to get corruption specific scenes. Currently not worth it but it's the most likely playthrough to get major changes in the future.
Simplest way to mod the game and get the most bang for your buck as of current version -> Use the console to increase skill and power by 1. This change allows you to play however you want up to the Aglaec vs Save Laurie choice.
Quick question. Does the male MC turn into a trap/futa/transgender? If so, I'll just skip this one.
MC uses his female form mostly for practical purposes, like going undercover, and it doesn't happen that often. If you actively pursue it, you can get a few scenes as either futa or female. Most of them are Female on Female or Futa on Female, but there are a few where MC has sex with males.