LMAO, none at all, if anything it was the complete opposite XD Small reminder, the 'medicine' stopped working right away, Asuna herself said so, Kirito's dick went back to normal, and it was AFTER THAT when Suguha seemingly did something more to him (As evidenced for how nervous/guilty she looked that very morning). THEN she went ahead and 'had a repeat' while Kazuto was in FOG with Asuna, clearly getting jealous when he said he was going inside to meet her. And during the restaurant scene after that she's not only very horny and happy, she even had a small Yandere moment where she went off about Asuna "neglecting her girlfriend duties" towards him
That's what makes it so hilarious, for all intents and purposes, and despite Fujino later maybe changing things around because of other reasons or because it's easier, but Suguha 100% LIKED fucking Kirito while he was asleep, and had 0 issues with his dick size despite experiencing Hebishima's Cliche NTR Chad Dick several times already XP Hell, even after that in FOG you see she not only fucked around with Hebishima to try and get him killed by the tree Boss, she even had happy hearts seeing Kirito be all cool saving the dude, so she most definitively was not in the "I suddenly don't care for him because his dick is small"-mode, but in "Want to have more rape-sex with Onii-chan/Yandere"-mode :3