I don't really have that one tag that makes me declare I MUST DOWNLOAD AND PLAY THIS GAME.
Some tags add more 'weight' to my interest to play a game, but it isn't a guarantee that I will download and play something just because it has a certain tag. Loli, pregnancy, futa/trans, tentacles, exhibition, incest, and RPGM are a few add a lot of weight to my interest in a game, but I don't need them to be one of the tags for me to be interested in a game.
Here is a good example:
Magical Girl Celesphonia It didn't hit every tag, but it hit quite a few and (IMO) it was a pretty damn good game. It wasn't a game where the main character had to be some degradation rape-toy to see sex scenes, you ... GASP ... had a choice on what porn you wanted to engage in. There was the standard rape on loss porn, but you didn't have to lose to get 'enough' porn.
However, on the other end of my tag spectrum, if it has gore, guro, vore, snuff, or scat as a tag, it doesn't matter if the game has every, single, tag that I do like, games with those tags get an instant 'nope the hell outta here'.