OK,I finally figured it out my self,here s my way to get it ,for those need it:
1,You need the second route of Maria get going,utill you ,Diege and eddy could fuck her in anal after taking drugs in eddy s house. This is the way you GET TO KNOWN BY EDDY.
If Maria is your gf now,then cheat her in your place by open the door except ABIGAIL bc you may want to get a NTR extra scene,if not,opening the door for Abigail will get Maria back to 0. After more than 5 times or better more,10 si good.then in the moring to day time,keep trying shower in your place,it a chance to get a Maria NTR scene,to to her after scene can get Maria go back 0 or 1. THen you can go SECOND ROUTE OF HER. BUT BETTER SAVE your game before the NTR,bc AFter second Maria woud hate you ,you can go back gf route for while,I saw the WT told it need quite a long time to go back gf.
2,Open Karen s story,Im NOT SURE which stage doed it need,Mine is all done with Karen,include normal and bum story.
3,Knock at EDDY S door(the hidden label next to your place),at day ,may be 15 00-17 00 is easier to get answered.
You MUST wait Diego to open,then you can go in. Eddy just turn down.
4,once you get inside,DO NOT,DO NOT ,DO NOT leave the house untill you see all 3 secene.You just skip time and see the changes of Karen and eddy.(I saw one,then leave,and try to knock at the door at other timing. This wouldnt work. How stupid I was)