If you let her take charge (by having a tiny cock or being caged), Tasha actually gets really into fucking you and forgets about making sure you're okay, so she strikes me as actually being really into topping, just too shy or nervous about driving you away to really act on those impulses until she's already balls deep. Ideally, I'd like to see that same dynamic if/when she gets a dom route, just removing the necessity of having a useless cock and getting more confident and dominant as a top as the route progresses.
Diana also seems like she prefers a dominant role from the way she acts (as well as her bad end if you think she's the culprit instead of Julia), but she's definitely crippled by a lack of content. It's been a long time, but I seem to recall her dominant sex scenes being more satisfying before Westane got rid of the stamina system, which removed some content or something. Ideally a dominant route for her would maintain her cool demeanor and add in a lot of humiliation, as well as perhaps involving milking a male character's prostate to get the cum she needs post-return.
Penny could really use a bit of a refresh in general, as well as some more fleshing out of her dominant path. It'd be nice to see her go from an inexperienced nervous domme to totally in control, instead of just flipping the switch from her being shy and horny to professional domina. I do love how cruel she is in the dom John path, so some natural cruel streak finally getting unearthed by the serums and allowed to run rampant would be nice to see in her own dom path.
As for the John route path, I like some cucking in with my femdom, personally, but yeah, there could stand to be a higher variety of stuff focusing on the girls and the players without John in that route. Like I said, though, the John route seems really unfinished. Like you don't even get variations on your dates with Penny and Tasha after they've been "corrupted," and there are tons of normal random encounters around the office that aren't consistent with their new, dominant attitudes. Tasha especially has virtually no interaction with the player character aside from being a plot device to progress the route, and aside from the training scenes, which I personally find pretty boring, Diana literally has no new scenes pre- and post-John.