So I think, if there is any consequence at all, the most dangerous route is the "Isabel" route. Just because of Antonio. One could of course speculate, what if Antonio "bites the dust". I mean, as the son of a powerful mafia boss, it's not exactly a very safe life. He certainly has enough enemies. That would of course open up some possibilities for the Isabell route. But that would be pretty fucked up

And it's not that I don't like Antonio - he's actually quite nice and I have to say I'd almost rather take the "Friendship" route with Isabel. But then again - she is pretty hot though...
And then there's Wilfred. Something tells me he wouldn't be very amused no matter which route you took. To be honest, I'm curious to see how Hopes will handle it with all the possibilities. Since all characters have a really deep personality, there will be different consequences depending on the route. If you are only after one girl, there shouldn't be too many consequences (well, except maybe Isabel and Cordia). But all of them? Damn, better make a will and do it soon.