After an update last week that seems to have disabled Smart App Control, my laptop (windows 11) started doing the same thing to most Renpy games that I haven't played before. If I played it before, Windows trusts it. If I haven't previously played it, there's an 80% chance that rather than getting the Windows Defender SmartScreen warning that I'm accustomed to and could choose to override, Windows completely blocks it (and logs nothing). I haven't dug into why Smart App Control is not working, so I'm not sure if MS deliberately changed something, but now I have to turn off "Check apps and files" under Reputation-based protection. Doing so, allows a different warning upon running the game, similar to what I used to get on Windows 8. This can be overridden and a check-box ticked to prevent it from asking again. Then I turn on "Check apps and files" under Reputation-based protection again. It's a nuisance, but not a huge one. Hope this helps.