There are some quirks but if your mods are up to date it shouldn't be a problem. As always, Basemental and Nisa are going to be a problem. You might want to grab a few mods from
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(free, public downloads) so the game doesn't randomly turn a bunch of NPCs into spellcasters and give them ugly random outfits in the magic zone.
Is your sim a spellcaster? There's a crash bug related to spellcaster idle animations. I don't know if it's related to your issue. I haven't had it happen to me yet.
After some reading, it happens when you exit CAS while your spellcaster sim is doing the spell cast idle animation. I probably haven't crashed because I use this mod that makes sims stand still in CAS.
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