Nope! I didn't want to go with drastic negative reactions for my first game so as of now, no relationship will negatively impact another one. IF it comes up in the future, you'll probably only miss out on some 100% loyalty content but it will never end the relationship.Will the Talitha romance close the Lyra course?
Example scenario - Talitha and Lyra both want to hang out with you on the same day - You pick one over the other - You get some nice scenes with the one you picked and miss out on the other one