If you skip content, you'll miss content ..... yeah, no fucking shit.
Perhaps the point was that, in many cases, skipping such content doesn't have a significant effect on the story (often because there isn't much content of that type in those games).
While futa/Trans and trap aren't my things, developers should create the games that interest them; if that's what floats this dev's boat, then that what he should work with.
Personally, I am one of those who get tired of posts saying, "Hey, if you'd just add in my favorite fetishes, and tone down the ones I don't like, this would be a good game." I can understand the desire to have a creator whose writing or art is enjoyable, but whose subject matter is not. But suggesting major changes of direction in terms of fetishes just barely makes more sense than telling someone writing a typical high school/college-based story that they should change it to be a space opera set on a spaceship, with no school involved.