@King Monkey Mon
This is what Irphaeus have said when he have implemented karma system. IIRC harem will be in game, but maybe it will be possible to get it only on mixed karma path. I'm not sure about it, but I think that I have seen it somewhere on this thread.
You win or loose Karma depending of your choice (some matter more than others...) :
Having a lot of Karma (
green choice) will open to you the
Lover route and ending.
Having mixed Karma (
green/
red choice) will open to you the
Opportunist route and ending.
Having a low Karma (
red choice) will open to you the
Vengeful route and ending.
It's not about win, or good and bad ending, but the path and ending you'll deserve after your choices along the game.