From a story prespective, I'd say Lana is a good candidate. In terms of narrative, she is more involved in the story and one of the first characters we meet. Her story is connected to the main plot so having sex with her is required to progress the story. So I say her and MC being the "canon" choice to lose their virginity to is not bad.
Not saying she is the only choice. I think Myrtle, Rose, or even Holly are good "Canon" choice to loose their virginity to, I just meant from a story prespective, their romances are just optional side stories.
Though it be funny in a twisted way if the matchmaker took it.