Hard core: If you set them off, the game will avoid that content, you won't see it, someone else will take care of it. If you allow it, you'll get a choice on how to act towards it.
Femdom: Same as hardcore, if you set it off, mc will atuomatically avoid it. If you leave it on, you'll get the choice if you want it or not. If you have maledom active, you'll dom that girl insted of her femdoming you.
If you keep femdom on, and maledom off, you won't be able to turn the tables on the girl. If you have maledom on, but femdom off, you won't be able to subdue a femdom girl (Jennika in this case).
Of course, Femdom and Maledom branchs will set a little bit of personality for the MC, where the femdom will make it more submissive, and the maledom will make him nothing sumbissive but a lot of confident. Which will also change some sex scenes and so.
THen again, being a maledom, doesn't mean you'll dom every girl. And then again, maledom doesn't mean you'll tie girls and do BDSM stuff, that's BDSM no Maledom (I know they usually go hand by hand, but they are different things).