No, you can go for any LI in the beginning. Not exactly sure if you had to make the choice yet since I haven't played 0.6 yet.
Kinda... you need to make decisions already on which Ink-Girl you focus more... or there is no progress. Its pretty much impossible to go for all the ink girls... Some can be pursued simultanisly... but most not.
And Zelda is a special case already, she doesnt like it one bit to see the MC kiss ANY other girl (like Kindra for example) and at the Halloweenparty there is such a scene. Zelda and sharing the MC? Doesnt look like it...
I would say, at this point its kinda like this...:
there are three "pools" of LIs in the game... (no specific order)
1 The Ink Girls
2 Kapuletti Industries including June, Kindra and Artemis.
3 Zelda
Though June and Zelda are Ink Girls, but they "work" differently...
The 2 pool is ALWAYS dateable... at this point. And simultan too. No consequences... well... if you go for Kindra and June they will share and like each other... looks like throuplepath. And Artemis might be included aswell. And you can date those and some Ink Girls too on top.
Zelda is a special case already as i said... if she sees the MC with someone other... not good.
All the other Ink Girls are kind of "ok" wiuth the MC going for different girls... but you have to decide already here and there cause you cant go on the dates with everyone. Missing out here, kinda stops the progress on the love route. It might be possible to progress anyways later on... but you will miss a lot of content with the girls already...
So its not really like making a "choice"... its more like... a "flow" Going on a date with Zelda rules out the possibilty to go on the date with a different girl and so on... Not going with Zelda closes her path pretty much entirely like i experienced it. So its not about a choice to pick, its more like "hm if i go on a date with her, i cant get the date with the other" and that sets the bar.