Ren'Py offers a tremendous amount of save slots, why do so many of you use only one????
I just save whenever anything interesting happens which I might want to see later, which tends to be every few scenes or so. I end up having 20+ pages of saves, depending on the length of the game. Just looking at my save screenshots helps me remember, more or less, what happened last few updates to most games.
Plus, if I screw up something, usually I can go back a few pages and try another option. Plus, like a few have said, even the longest game here, can be zipped through in 10 or 15 minutes using control and vaguelly remembering your last choices.
But, I have very low patience for sandbox games where the saves don't work. Occasionally, one will be interesting enough to play for one playthrough, but if the dev messes up the saves, I am done. There is no way in hell I am going back to replay Summertime Saga, Cure my Addiction, or something like House Party if my saves no longer work.
It's just not worth it. It was painful enough the first time.