The game is a comedy, often the events are bordering on ridiculous (a lot of Derek's hijinks), so while the drama is to be taken somewhat seriously, I don't think it's meant to be all that stressful.
People are constantly panicking that the college is gonna burn down and the mc will only be able to save 1 our of the 20+ girls, but this game really isn't headed in that direction.
It's fun to theorise so many things as the game has heaps of open ended details that are slowly being closed, but it's pretty safe to say that none of it matters.
Of all the drama, Maya's oppressive father is probably the biggest issue. In real life, this would be a source of significant depression for Maya, and as a friend of Maya's, the mc would be quite sympathetic.
In real life, all the other drama can typically be ignored:
- The mc pretty much ignored Tybalt's threat and kept seeing Jill anyway,
- The jocks are no big drama for the mc, he's put them in their place a number of times (I'm not convinced they trashed the DIK's mansion),
- Burke poses no issue towards the mc,
- Quinn is either the mc's friend or she just ignores him; and
- At the moment, Vinny is nothing.
So basically it's just a fun ride. DPC gave his disclaimer at the beginning because, depending on your personal experience, some delicate subjects are breached, but, contrary to popular belief, I don't think he's planning to destroy the players' souls.