What I'd expect from the drug part is that Buddy is effectively dead. That is to say actually dead, comatose or imprisoned with no chance of escape or asserting control from within. Vinny however is not caught and with Buddy out of the picture he'll see himself as the new big fish. He is going to do something incredibly stupid that is also dangerous as hell. He is either naive about the consequences he is going to have to face, won't think that far ahead or just doesn't give a damn. People like that are capable of some really nasty shit, though they don't tend to last long.
Nick will have a moment of truth that relates to helping Vinny. Not really sure how, but I'd say player choices that already started happening in ep 11 will decide the outcome. Vinny will go down one way or another, but how much goes down with him? Quinn's and Riona's fates will probably hang in the balance.