In many other "incestuous" games, designers have found effective ways to circumvent Patreon's rules, allowing them to continue their development.
For example, it would be enough here to make a prologue (as we have seen in some sagas of films) Big Brother - The Beginning in which it would be explained that:
1) Ann and Kira's parents could not have children, so the 2 sisters were adopted at birth
2) Ann could not have children or she wanted to continue in her parents' footsteps and so Liza, Alice and Max were also adopted.
Thus, there is no more consanguinity between any of the characters, the rules enacted by Patreon are respected, and the game can continue to evolve without having anything to change to the existing game.